Drug interactions
Indinavir + Lacosamide
Severity: Minor
Indinavir and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, a minor pathway for lacosamide metabolism. Clinically relevant increases in lacosamide exposure are unlikely.
What this interaction means in plain words
Indinavir and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition modestly slows lacosamide metabolism.
What to do
No routine dose change is needed. Monitor for dizziness, ataxia and PR prolongation, particularly in renal or hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Indinavir with Lacosamide?
MediHelp rates the interaction as minor. Indinavir and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4, a minor pathway for lacosamide metabolism. Clinically relevant increases in lacosamide exposure are unlikely.
How serious is the interaction between Indinavir and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, ataxia and PR prolongation, particularly in renal or hepatic impairment.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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