Drug interactions
Indinavir + Linagliptin
Severity: Minor
Indinavir and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise linagliptin levels, though the effect is expected to be modest given linagliptin's limited metabolism. Protease inhibitors may also cause insulin resistance and hyperglycemia, working against glycemic control.
What this interaction means in plain words
Indinavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4/P-gp inhibition by indinavir may increase linagliptin exposure, while protease inhibitor-related insulin resistance antagonizes glucose lowering.
What to do
No linagliptin dose change is needed; monitor blood glucose and HbA1c during indinavir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Indinavir with Linagliptin?
MediHelp rates the interaction as minor. Indinavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may raise linagliptin levels, though the effect is expected to be modest given linagliptin's limited metabolism. Protease inhibitors may also cause insulin resistance and hyperglycemia, working against glycemic control.
How serious is the interaction between Indinavir and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose change is needed; monitor blood glucose and HbA1c during indinavir therapy.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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