Drug interactions
Indinavir + Mirtazapine
Severity: Moderate
Indinavir and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor, and CYP3A4 is one of the enzymes that metabolize mirtazapine. Mirtazapine exposure may increase, causing more sedation and other dose-related adverse effects.
What this interaction means in plain words
Indinavir and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces mirtazapine clearance.
What to do
Monitor for sedation, dizziness and other adverse effects, and reduce the mirtazapine dose if needed. Reassess the dose when indinavir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Indinavir with Mirtazapine?
MediHelp rates the interaction as moderate. Indinavir and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a potent CYP3A4 inhibitor, and CYP3A4 is one of the enzymes that metabolize mirtazapine. Mirtazapine exposure may increase, causing more sedation and other dose-related adverse effects.
How serious is the interaction between Indinavir and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other adverse effects, and reduce the mirtazapine dose if needed. Reassess the dose when indinavir is stopped.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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