Drug interactions
Indinavir + Modafinil
Severity: Moderate
Indinavir and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir strongly inhibits CYP3A4 and may increase modafinil concentrations, potentially increasing adverse effects such as anxiety, headache, insomnia and rash. Modafinil may in turn lower indinavir levels through weak CYP3A4 induction.
What this interaction means in plain words
Indinavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces modafinil clearance; modafinil's weak induction may lower indinavir exposure.
What to do
Monitor for modafinil adverse effects and consider a lower dose; watch virologic response to antiretroviral therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Indinavir with Modafinil?
MediHelp rates the interaction as moderate. Indinavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir strongly inhibits CYP3A4 and may increase modafinil concentrations, potentially increasing adverse effects such as anxiety, headache, insomnia and rash. Modafinil may in turn lower indinavir levels through weak CYP3A4 induction.
How serious is the interaction between Indinavir and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and consider a lower dose; watch virologic response to antiretroviral therapy.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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