Drug interactions
Indinavir + Mometasone
Severity: Moderate
Indinavir and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and can raise systemic mometasone levels. This increases the risk of Cushing's syndrome and adrenal suppression with prolonged use.
What this interaction means in plain words
Indinavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated mometasone metabolism.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indinavir and Mometasone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Frequently asked questions
Can I take Indinavir with Mometasone?
MediHelp rates the interaction as moderate. Indinavir and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and can raise systemic mometasone levels. This increases the risk of Cushing's syndrome and adrenal suppression with prolonged use.
How serious is the interaction between Indinavir and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression. Consider beclomethasone for long-term therapy.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
