Drug interactions
Indinavir + Nevirapine
Severity: Major
Indinavir and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine lowers indinavir concentrations, which may cause loss of antiviral efficacy. Indinavir may modestly raise nevirapine levels.
What this interaction means in plain words
Indinavir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing indinavir metabolism.
What to do
Use ritonavir-boosted indinavir with HIV RNA monitoring, or choose an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Indinavir with Nevirapine?
MediHelp rates the interaction as major. Indinavir and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine lowers indinavir concentrations, which may cause loss of antiviral efficacy. Indinavir may modestly raise nevirapine levels.
How serious is the interaction between Indinavir and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use ritonavir-boosted indinavir with HIV RNA monitoring, or choose an alternative regimen.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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