Drug interactions
Indinavir + Ondansetron
Severity: Minor
Indinavir and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, one of several pathways that clear ondansetron, so ondansetron exposure may rise modestly. Because ondansetron is cleared by multiple enzymes, the effect is usually small and clinically minor.
What this interaction means in plain words
Indinavir and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated ondansetron metabolism by indinavir, with other pathways compensating.
What to do
No empirical dose change is needed for ondansetron. Obtain an ECG if there are other QT risk factors or high doses are given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Indinavir with Ondansetron?
MediHelp rates the interaction as minor. Indinavir and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4, one of several pathways that clear ondansetron, so ondansetron exposure may rise modestly. Because ondansetron is cleared by multiple enzymes, the effect is usually small and clinically minor.
How serious is the interaction between Indinavir and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed for ondansetron. Obtain an ECG if there are other QT risk factors or high doses are given.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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