Drug interactions
Indinavir + Ranolazine
Severity: Contraindicated
Indinavir and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A inhibitor that increases ranolazine exposure substantially. This raises the risk of QT prolongation and dose-related adverse effects.
What this interaction means in plain words
Indinavir and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 metabolism of ranolazine by indinavir.
What to do
Do not coadminister; ranolazine labeling contraindicates strong CYP3A inhibitors. Choose a different antianginal during HIV protease inhibitor therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Indinavir with Ranolazine?
MediHelp rates the interaction as contraindicated. Indinavir and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Indinavir is a potent CYP3A inhibitor that increases ranolazine exposure substantially. This raises the risk of QT prolongation and dose-related adverse effects.
How serious is the interaction between Indinavir and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; ranolazine labeling contraindicates strong CYP3A inhibitors. Choose a different antianginal during HIV protease inhibitor therapy.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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