Drug interactions
Indinavir + Ruxolitinib
Severity: Major
Indinavir and Ruxolitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 strongly and raises ruxolitinib exposure, which can worsen thrombocytopenia, neutropenia and infection risk.
What this interaction means in plain words
Indinavir and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by indinavir reduces ruxolitinib metabolism.
What to do
Reduce the ruxolitinib dose per labeling for strong CYP3A4 inhibitors. Monitor blood counts regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Indinavir with Ruxolitinib?
MediHelp rates the interaction as major. Indinavir and Ruxolitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4 strongly and raises ruxolitinib exposure, which can worsen thrombocytopenia, neutropenia and infection risk.
How serious is the interaction between Indinavir and Ruxolitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose per labeling for strong CYP3A4 inhibitors. Monitor blood counts regularly.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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