Drug interactions
Indinavir + Temsirolimus
Severity: Major
Indinavir and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and can substantially raise exposure to temsirolimus and its active metabolite sirolimus. This increases the risk of mTOR-related toxicity such as myelosuppression, mucositis, infection, hyperglycemia, and pneumonitis.
What this interaction means in plain words
Indinavir and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Indinavir inhibits CYP3A4-mediated metabolism of temsirolimus and sirolimus.
What to do
Avoid the combination if possible and choose an alternative antiretroviral. If it is unavoidable, reduce the temsirolimus dose per labeling and monitor closely for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Indinavir with Temsirolimus?
MediHelp rates the interaction as major. Indinavir and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir is a strong CYP3A4 inhibitor and can substantially raise exposure to temsirolimus and its active metabolite sirolimus. This increases the risk of mTOR-related toxicity such as myelosuppression, mucositis, infection, hyperglycemia, and pneumonitis.
How serious is the interaction between Indinavir and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an alternative antiretroviral. If it is unavoidable, reduce the temsirolimus dose per labeling and monitor closely for toxicity.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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