Drug interactions
Indinavir + Trazodone
Severity: Major
Indinavir and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, which is the main pathway for trazodone metabolism, so trazodone concentrations can rise. This may cause excessive sedation, hypotension, and QT prolongation.
What this interaction means in plain words
Indinavir and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism by indinavir.
What to do
Start trazodone at a low dose and titrate cautiously, watching for sedation, dizziness and arrhythmia symptoms. Consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Indinavir with Trazodone?
MediHelp rates the interaction as major. Indinavir and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4, which is the main pathway for trazodone metabolism, so trazodone concentrations can rise. This may cause excessive sedation, hypotension, and QT prolongation.
How serious is the interaction between Indinavir and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate cautiously, watching for sedation, dizziness and arrhythmia symptoms. Consider an ECG in patients with other QT risk factors.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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