Drug interactions
Indinavir + Trimipramine
Severity: Moderate
Indinavir and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, which contributes to trimipramine metabolism, so trimipramine levels may rise. This can increase anticholinergic, sedative and cardiac adverse effects.
What this interaction means in plain words
Indinavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of trimipramine by indinavir.
What to do
Monitor for tricyclic toxicity and consider an ECG; reduce the trimipramine dose or use plasma level monitoring if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Indinavir with Trimipramine?
MediHelp rates the interaction as moderate. Indinavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, which contributes to trimipramine metabolism, so trimipramine levels may rise. This can increase anticholinergic, sedative and cardiac adverse effects.
How serious is the interaction between Indinavir and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider an ECG; reduce the trimipramine dose or use plasma level monitoring if available.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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