Drug interactions
Indinavir + Vortioxetine
Severity: Moderate
Indinavir and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and may raise vortioxetine concentrations. Because CYP2D6 is the major pathway for vortioxetine, the increase is probably modest but may worsen nausea and other adverse effects.
What this interaction means in plain words
Indinavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by indinavir reduces the minor oxidative clearance pathway of vortioxetine.
What to do
Monitor tolerability, particularly nausea and serotonergic effects, and lower the vortioxetine dose if adverse effects occur. Be more cautious in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Indinavir with Vortioxetine?
MediHelp rates the interaction as moderate. Indinavir and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and may raise vortioxetine concentrations. Because CYP2D6 is the major pathway for vortioxetine, the increase is probably modest but may worsen nausea and other adverse effects.
How serious is the interaction between Indinavir and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability, particularly nausea and serotonergic effects, and lower the vortioxetine dose if adverse effects occur. Be more cautious in CYP2D6 poor metabolizers.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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