Drug interactions
Indinavir + Zileuton
Severity: Minor
Indinavir and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may increase zileuton concentrations. Increased exposure could raise the risk of hepatic and gastrointestinal adverse effects.
What this interaction means in plain words
Indinavir and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated zileuton metabolism by indinavir, which is predicted rather than well documented.
What to do
Continue both drugs with routine ALT monitoring for zileuton and review for adverse effects after starting indinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Indinavir with Zileuton?
MediHelp rates the interaction as minor. Indinavir and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may increase zileuton concentrations. Increased exposure could raise the risk of hepatic and gastrointestinal adverse effects.
How serious is the interaction between Indinavir and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue both drugs with routine ALT monitoring for zileuton and review for adverse effects after starting indinavir.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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