Drug interactions
Indinavir + Zonisamide
Severity: Moderate
Indinavir and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise zonisamide concentrations. Both drugs are also associated with kidney stones, so the combination may add to that risk.
What this interaction means in plain words
Indinavir and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces zonisamide metabolism, with additive nephrolithiasis risk.
What to do
Monitor for zonisamide adverse effects and keep patients well hydrated to limit stone formation. Reduce the zonisamide dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Indinavir with Zonisamide?
MediHelp rates the interaction as moderate. Indinavir and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise zonisamide concentrations. Both drugs are also associated with kidney stones, so the combination may add to that risk.
How serious is the interaction between Indinavir and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide adverse effects and keep patients well hydrated to limit stone formation. Reduce the zonisamide dose if toxicity occurs.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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