Drug interactions
Indomethacin + Ipratropium-salbutamol
Severity: Minor
Indomethacin and Ipratropium-salbutamol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically important interaction between inhaled salbutamol or ipratropium and indomethacin is established. NSAIDs can modestly raise potassium while salbutamol lowers it, so effects are likely to offset. NSAID-induced bronchospasm in sensitive asthmatics is a separate concern.
What this interaction means in plain words
Indomethacin and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Opposing minor effects on serum potassium; no meaningful interaction mechanism established.
What to do
No action is needed for the combination; ask asthmatic patients about prior NSAID-induced bronchospasm.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium-salbutamol
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Ipratropium-salbutamol?
MediHelp rates the interaction as minor. Indomethacin and Ipratropium-salbutamol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically important interaction between inhaled salbutamol or ipratropium and indomethacin is established. NSAIDs can modestly raise potassium while salbutamol lowers it, so effects are likely to offset. NSAID-induced bronchospasm in sensitive asthmatics is a separate concern.
How serious is the interaction between Indomethacin and Ipratropium-salbutamol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for the combination; ask asthmatic patients about prior NSAID-induced bronchospasm.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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