Drug interactions
Indomethacin + Irbesartan
Severity: Moderate
Indomethacin and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the antihypertensive effect of irbesartan and, together, the two drugs raise the risk of acute kidney injury and hyperkalemia. The risk is greatest in older, volume-depleted, or renally impaired patients.
What this interaction means in plain words
Indomethacin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory renal prostaglandins, reducing glomerular perfusion already dependent on angiotensin blockade, and impair potassium excretion.
What to do
Monitor blood pressure, serum creatinine, and potassium after starting the combination. Ensure hydration and avoid long-term NSAID use, particularly in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Indomethacin with Irbesartan?
MediHelp rates the interaction as moderate. Indomethacin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the antihypertensive effect of irbesartan and, together, the two drugs raise the risk of acute kidney injury and hyperkalemia. The risk is greatest in older, volume-depleted, or renally impaired patients.
How serious is the interaction between Indomethacin and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine, and potassium after starting the combination. Ensure hydration and avoid long-term NSAID use, particularly in high-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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