Drug interactions
Indomethacin + Lesinurad
Severity: Minor
Indomethacin and Lesinurad: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is metabolized mainly by CYP2C9, and indomethacin is only a weak inhibitor, so any increase in exposure is expected to be small. Both drugs can affect renal function, which is relevant because lesinurad carries a renal adverse event warning.
What this interaction means in plain words
Indomethacin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
Why it happens
Possible weak CYP2C9 inhibition by indomethacin; additive renal effects are theoretical.
What to do
No dose adjustment is needed, but monitor serum creatinine and renal function during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Frequently asked questions
Can I take Indomethacin with Lesinurad?
MediHelp rates the interaction as minor. Indomethacin and Lesinurad have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lesinurad is metabolized mainly by CYP2C9, and indomethacin is only a weak inhibitor, so any increase in exposure is expected to be small. Both drugs can affect renal function, which is relevant because lesinurad carries a renal adverse event warning.
How serious is the interaction between Indomethacin and Lesinurad?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed, but monitor serum creatinine and renal function during combined use.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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