Drug interactions
Indomethacin + Levofloxacin
Severity: Moderate
Indomethacin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulation and seizure risk of fluoroquinolones. The effect is uncommon but important in patients with epilepsy, CNS disease, renal impairment, or the elderly.
What this interaction means in plain words
Indomethacin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA binding at GABA-A receptors, possibly potentiated by NSAIDs.
What to do
Avoid in patients with a seizure history or lowered seizure threshold; otherwise use the lowest effective doses and stop levofloxacin if neurologic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Indomethacin with Levofloxacin?
MediHelp rates the interaction as moderate. Indomethacin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulation and seizure risk of fluoroquinolones. The effect is uncommon but important in patients with epilepsy, CNS disease, renal impairment, or the elderly.
How serious is the interaction between Indomethacin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with a seizure history or lowered seizure threshold; otherwise use the lowest effective doses and stop levofloxacin if neurologic symptoms appear.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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