Drug interactions
Indomethacin + Nebivolol
Severity: Moderate
Indomethacin and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular indomethacin use may blunt the antihypertensive effect of nebivolol. Blood pressure control may worsen after NSAID initiation.
What this interaction means in plain words
Indomethacin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory prostaglandin synthesis and cause sodium and fluid retention.
What to do
Monitor blood pressure during concomitant use, especially beyond one week. Adjust antihypertensive therapy or use a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Indomethacin with Nebivolol?
MediHelp rates the interaction as moderate. Indomethacin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular indomethacin use may blunt the antihypertensive effect of nebivolol. Blood pressure control may worsen after NSAID initiation.
How serious is the interaction between Indomethacin and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concomitant use, especially beyond one week. Adjust antihypertensive therapy or use a non-NSAID analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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