Drug interactions
Indomethacin + Neomycin
Severity: Minor
Indomethacin and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin reduces renal clearance of aminoglycosides, best documented in preterm neonates given parenteral aminoglycosides. Oral neomycin is poorly absorbed, so the effect is small unless gut permeability or renal function is impaired.
What this interaction means in plain words
Indomethacin and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Neomycin belongs to Anti Bacterial.
Why it happens
Prostaglandin inhibition lowers renal blood flow and glomerular filtration, slowing aminoglycoside elimination.
What to do
No routine action is needed with oral neomycin in adults. In neonates or patients with renal impairment, monitor renal function and consider aminoglycoside levels if absorption is likely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Neomycin?
MediHelp rates the interaction as minor. Indomethacin and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indomethacin reduces renal clearance of aminoglycosides, best documented in preterm neonates given parenteral aminoglycosides. Oral neomycin is poorly absorbed, so the effect is small unless gut permeability or renal function is impaired.
How serious is the interaction between Indomethacin and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with oral neomycin in adults. In neonates or patients with renal impairment, monitor renal function and consider aminoglycoside levels if absorption is likely.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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