Drug interactions
Indomethacin + Phentolamine
Severity: Minor
Indomethacin and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the blood pressure lowering effect of vasodilating antihypertensives. This is a theoretical concern with phentolamine, which is generally used short term for pheochromocytoma or extravasation.
What this interaction means in plain words
Indomethacin and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
Indomethacin inhibits vasodilatory prostaglandin synthesis and promotes sodium and fluid retention, opposing alpha-blocker vasodilation.
What to do
Monitor blood pressure response when phentolamine is used with indomethacin and titrate phentolamine as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Indomethacin with Phentolamine?
MediHelp rates the interaction as minor. Indomethacin and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce the blood pressure lowering effect of vasodilating antihypertensives. This is a theoretical concern with phentolamine, which is generally used short term for pheochromocytoma or extravasation.
How serious is the interaction between Indomethacin and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure response when phentolamine is used with indomethacin and titrate phentolamine as needed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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