Drug interactions
Indomethacin + Pralatrexate
Severity: Moderate
Indomethacin and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal elimination of pralatrexate and increase exposure, with risk of mucositis and other toxicity. NSAID-related renal effects may add to this risk.
What this interaction means in plain words
Indomethacin and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Indomethacin reduces renal blood flow and may compete for renal tubular secretion, decreasing pralatrexate clearance.
What to do
Monitor for mucositis, myelosuppression and renal function, and reduce the pralatrexate dose or avoid the NSAID if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Indomethacin with Pralatrexate?
MediHelp rates the interaction as moderate. Indomethacin and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the renal elimination of pralatrexate and increase exposure, with risk of mucositis and other toxicity. NSAID-related renal effects may add to this risk.
How serious is the interaction between Indomethacin and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mucositis, myelosuppression and renal function, and reduce the pralatrexate dose or avoid the NSAID if toxicity develops.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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