Drug interactions
Indomethacin + Probenecid
Severity: Moderate
Indomethacin and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal clearance of indomethacin, raising its plasma levels and the risk of NSAID adverse effects. Indomethacin may also modestly interfere with the uricosuric effect of probenecid.
What this interaction means in plain words
Indomethacin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal organic anion transporters that secrete indomethacin, and indomethacin competes for the same pathway.
What to do
Consider a lower indomethacin dose and monitor for GI, renal and CNS adverse effects. Check urate control if both are used long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Indomethacin with Probenecid?
MediHelp rates the interaction as moderate. Indomethacin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal clearance of indomethacin, raising its plasma levels and the risk of NSAID adverse effects. Indomethacin may also modestly interfere with the uricosuric effect of probenecid.
How serious is the interaction between Indomethacin and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower indomethacin dose and monitor for GI, renal and CNS adverse effects. Check urate control if both are used long term.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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