Drug interactions
Indomethacin + Sertraline
Severity: Moderate
Indomethacin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining sertraline with an NSAID increases the risk of bleeding, especially in the upper gastrointestinal tract. Risk is higher in older adults and with prior ulcer disease.
What this interaction means in plain words
Indomethacin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion combined with NSAID platelet inhibition and gastric mucosal injury gives additive bleeding risk.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Prefer paracetamol or a non-NSAID alternative when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Indomethacin with Sertraline?
MediHelp rates the interaction as moderate. Indomethacin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining sertraline with an NSAID increases the risk of bleeding, especially in the upper gastrointestinal tract. Risk is higher in older adults and with prior ulcer disease.
How serious is the interaction between Indomethacin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Prefer paracetamol or a non-NSAID alternative when feasible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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