Drug interactions
Indomethacin + Terbinafine
Severity: Minor
Indomethacin and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no established clinically significant interaction. Terbinafine is a CYP2D6 inhibitor and indomethacin is not a notable CYP2C9 inhibitor, so a rise in terbinafine exposure is unlikely.
What this interaction means in plain words
Indomethacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Terbinafine belongs to Anti Fungals.
Why it happens
No established mechanism; the proposed CYP2C9 effect is theoretical.
What to do
No dose adjustment is needed; routine monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Indomethacin with Terbinafine?
MediHelp rates the interaction as minor. Indomethacin and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no established clinically significant interaction. Terbinafine is a CYP2D6 inhibitor and indomethacin is not a notable CYP2C9 inhibitor, so a rise in terbinafine exposure is unlikely.
How serious is the interaction between Indomethacin and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine monitoring is sufficient.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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