Drug interactions
Indomethacin + Tolazamide
Severity: Moderate
Indomethacin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is inconsistent and more likely with other NSAIDs.
What this interaction means in plain words
Indomethacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement from plasma protein binding and prostaglandin-related effects on insulin secretion; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping indomethacin and teach patients the signs of hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Indomethacin with Tolazamide?
MediHelp rates the interaction as moderate. Indomethacin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is inconsistent and more likely with other NSAIDs.
How serious is the interaction between Indomethacin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping indomethacin and teach patients the signs of hypoglycemia. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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