Drug interactions
Infliximab + Influenza virus vaccine quadrivalent cell-cultured
Severity: Minor
Infliximab and Influenza virus vaccine quadrivalent cell-cultured: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infliximab may blunt the antibody response to inactivated influenza vaccines, so protection may be lower than expected. The vaccine is non-live and is not contraindicated, and vaccination is generally recommended in patients on anti-TNF therapy.
What this interaction means in plain words
Infliximab and Influenza virus vaccine quadrivalent cell-cultured have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF blockade causes immunosuppression that can modestly reduce vaccine-induced antibody responses.
What to do
Give the inactivated vaccine annually as indicated, ideally before starting or between infliximab doses. Do not delay vaccination, and do not assume full protection if exposed to influenza.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates the interaction as minor. Infliximab and Influenza virus vaccine quadrivalent cell-cultured have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infliximab may blunt the antibody response to inactivated influenza vaccines, so protection may be lower than expected. The vaccine is non-live and is not contraindicated, and vaccination is generally recommended in patients on anti-TNF therapy.
How serious is the interaction between Infliximab and Influenza virus vaccine quadrivalent cell-cultured?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually as indicated, ideally before starting or between infliximab doses. Do not delay vaccination, and do not assume full protection if exposed to influenza.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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