Drug interactions
Infliximab + Influenza virus vaccine quadrivalent
Severity: Minor
Infliximab and Influenza virus vaccine quadrivalent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inactivated influenza vaccine is safe with infliximab, though the antibody response may be modestly reduced. Annual vaccination is still recommended because influenza carries higher risk in these patients.
What this interaction means in plain words
Infliximab and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
TNF-alpha inhibition may modestly blunt humoral response to vaccine antigens.
What to do
Give the inactivated injectable vaccine annually; do not use the live intranasal formulation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as minor. Infliximab and Influenza virus vaccine quadrivalent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inactivated influenza vaccine is safe with infliximab, though the antibody response may be modestly reduced. Annual vaccination is still recommended because influenza carries higher risk in these patients.
How serious is the interaction between Infliximab and Influenza virus vaccine quadrivalent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated injectable vaccine annually; do not use the live intranasal formulation.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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