Drug interactions
Infliximab + Japanese encephalitis virus vaccine
Severity: Moderate
Infliximab and Japanese encephalitis virus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The commonly used Japanese encephalitis vaccine is inactivated, so there is no risk of vaccine-strain infection. Infliximab may reduce the immune response, leaving travelers with less protection than expected.
What this interaction means in plain words
Infliximab and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF blockade-related immunosuppression may attenuate the antibody response to the vaccine.
What to do
Vaccinate well before travel, ideally before starting or at the trough of infliximab dosing, and consider checking serologic response where available. Reinforce mosquito-avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Japanese encephalitis virus vaccine?
MediHelp rates the interaction as moderate. Infliximab and Japanese encephalitis virus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The commonly used Japanese encephalitis vaccine is inactivated, so there is no risk of vaccine-strain infection. Infliximab may reduce the immune response, leaving travelers with less protection than expected.
How serious is the interaction between Infliximab and Japanese encephalitis virus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate well before travel, ideally before starting or at the trough of infliximab dosing, and consider checking serologic response where available. Reinforce mosquito-avoidance measures.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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