Drug interactions
Infliximab + Ofatumumab sc
Severity: Major
Infliximab and Ofatumumab sc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and infliximab blocks TNF, so combining them may increase the risk of serious infections. Switching between such therapies also requires attention to residual immune effects.
What this interaction means in plain words
Infliximab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression via B-cell depletion and TNF-alpha inhibition.
What to do
Avoid concurrent use where possible and monitor for infection. When switching, allow for the duration of effect of the earlier drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Ofatumumab sc?
MediHelp rates the interaction as major. Infliximab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ofatumumab depletes B cells and infliximab blocks TNF, so combining them may increase the risk of serious infections. Switching between such therapies also requires attention to residual immune effects.
How serious is the interaction between Infliximab and Ofatumumab sc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor for infection. When switching, allow for the duration of effect of the earlier drug.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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