Drug interactions
Infliximab + Olaparib
Severity: Moderate
Infliximab and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia and neutropenia, and infliximab adds immunosuppression, so infection risk may rise. A direct pharmacokinetic interaction is not expected.
What this interaction means in plain words
Infliximab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression; no pharmacokinetic mechanism.
What to do
Monitor complete blood counts and signs of infection. Reassess the need for infliximab if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Infliximab with Olaparib?
MediHelp rates the interaction as moderate. Infliximab and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes anemia and neutropenia, and infliximab adds immunosuppression, so infection risk may rise. A direct pharmacokinetic interaction is not expected.
How serious is the interaction between Infliximab and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection. Reassess the need for infliximab if cytopenias develop.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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