Drug interactions
Infliximab + Rabies vaccine
Severity: Moderate
Infliximab and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabies vaccine is non-live, so it can be given, but infliximab may reduce the antibody response. Because rabies is almost always fatal, an inadequate response is clinically important in exposed or at-risk patients.
What this interaction means in plain words
Infliximab and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
TNF blockade-related immunosuppression may blunt vaccine-induced antibody production.
What to do
Vaccinate as indicated and check rabies neutralizing antibody titers after pre-exposure vaccination. For post-exposure treatment, give the full vaccine course with immune globulin as appropriate and verify the response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Rabies vaccine?
MediHelp rates the interaction as moderate. Infliximab and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabies vaccine is non-live, so it can be given, but infliximab may reduce the antibody response. Because rabies is almost always fatal, an inadequate response is clinically important in exposed or at-risk patients.
How serious is the interaction between Infliximab and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated and check rabies neutralizing antibody titers after pre-exposure vaccination. For post-exposure treatment, give the full vaccine course with immune globulin as appropriate and verify the response.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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