Drug interactions
Infliximab + Rotavirus oral vaccine live
Severity: Major
Infliximab and Rotavirus oral vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine is a live oral vaccine. Infants exposed to infliximab, especially through maternal treatment during pregnancy, may be at risk of vaccine-strain infection, and immunosuppressed patients may respond poorly.
What this interaction means in plain words
Infliximab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
TNF inhibition impairs immune control of live attenuated virus replication.
What to do
Avoid in patients receiving infliximab. For infants exposed in utero, delay the vaccine until the infliximab exposure window has passed, typically about 6 months, per local guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Rotavirus oral vaccine live?
MediHelp rates the interaction as major. Infliximab and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rotavirus vaccine is a live oral vaccine. Infants exposed to infliximab, especially through maternal treatment during pregnancy, may be at risk of vaccine-strain infection, and immunosuppressed patients may respond poorly.
How serious is the interaction between Infliximab and Rotavirus oral vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients receiving infliximab. For infants exposed in utero, delay the vaccine until the infliximab exposure window has passed, typically about 6 months, per local guidance.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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