Drug interactions
Infliximab + Typhoid vaccine live
Severity: Contraindicated
Infliximab and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated typhoid vaccine could cause systemic infection from the vaccine strain in patients immunosuppressed by infliximab. The vaccine response may also be reduced.
What this interaction means in plain words
Infliximab and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs immune control of live attenuated bacteria.
What to do
Avoid the live oral vaccine and use the inactivated injectable typhoid vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Infliximab and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The oral live attenuated typhoid vaccine could cause systemic infection from the vaccine strain in patients immunosuppressed by infliximab. The vaccine response may also be reduced.
How serious is the interaction between Infliximab and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral vaccine and use the inactivated injectable typhoid vaccine instead.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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