Drug interactions
Infliximab + Yellow fever vaccine
Severity: Contraindicated
Infliximab and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is live attenuated and has caused serious viscerotropic and neurotropic disease in immunosuppressed people. Infliximab increases this risk and may reduce protection.
What this interaction means in plain words
Infliximab and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition impairs immune control of live attenuated virus replication.
What to do
Avoid the vaccine during infliximab therapy; advise against travel to endemic areas, or provide a medical exemption letter if travel is unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Infliximab with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Infliximab and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is live attenuated and has caused serious viscerotropic and neurotropic disease in immunosuppressed people. Infliximab increases this risk and may reduce protection.
How serious is the interaction between Infliximab and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the vaccine during infliximab therapy; advise against travel to endemic areas, or provide a medical exemption letter if travel is unavoidable.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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