Drug interactions
Influenza virus vaccine adjuvanted + Temozolomide
Severity: Moderate
Influenza virus vaccine adjuvanted and Temozolomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temozolomide-related immunosuppression may reduce antibody responses to the adjuvanted H5N1 vaccine, so protection may be incomplete.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-related immunosuppression reduces vaccine immunogenicity.
What to do
Time vaccination before chemotherapy or at count recovery when possible, and maintain other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temozolomide
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Temozolomide?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temozolomide-related immunosuppression may reduce antibody responses to the adjuvanted H5N1 vaccine, so protection may be incomplete.
How serious is the interaction between Influenza virus vaccine adjuvanted and Temozolomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Time vaccination before chemotherapy or at count recovery when possible, and maintain other preventive measures.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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