Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Temozolomide
Severity: Minor
Influenza virus vaccine quadrivalent adjuvanted and Temozolomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temozolomide-induced lymphopenia and myelosuppression may blunt the antibody response to inactivated influenza vaccine. The vaccine is not harmful, but protection may be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Temozolomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cytotoxic suppression of lymphocytes may reduce vaccine-induced immune response.
What to do
Do not withhold the vaccine, since influenza protection matters in cancer patients. Where feasible, vaccinate before starting chemotherapy or between cycles when counts recover.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temozolomide
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Temozolomide?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent adjuvanted and Temozolomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temozolomide-induced lymphopenia and myelosuppression may blunt the antibody response to inactivated influenza vaccine. The vaccine is not harmful, but protection may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Temozolomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the vaccine, since influenza protection matters in cancer patients. Where feasible, vaccinate before starting chemotherapy or between cycles when counts recover.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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