Drug interactions
Influenza virus vaccine quadrivalent + Temsirolimus
Severity: Moderate
Influenza virus vaccine quadrivalent and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may blunt the antibody response to inactivated influenza vaccine, reducing protection. The vaccine is still generally recommended for patients with cancer because influenza can be severe.
What this interaction means in plain words
Influenza virus vaccine quadrivalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses lymphocyte activation and so lessens vaccine-induced antibody production.
What to do
Give the inactivated vaccine annually, ideally before starting temsirolimus. Do not withhold it because of expected reduced response, and keep the patient's other protective measures in place.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza virus vaccine quadrivalent and Temsirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent with Temsirolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may blunt the antibody response to inactivated influenza vaccine, reducing protection. The vaccine is still generally recommended for patients with cancer because influenza can be severe.
How serious is the interaction between Influenza virus vaccine quadrivalent and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine annually, ideally before starting temsirolimus. Do not withhold it because of expected reduced response, and keep the patient's other protective measures in place.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
