Drug reference
leflunomide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (DMARDs)
Mechanism of action
Not fully understood, Metabolite inhibits pyrimidine nucleotide synthesis; antiproliferative for T-cells
Common side effects
- Alopecia
- Rash
- Nausea
- Hypertension
- Respiratory infections
- Bronchitis
- Diarrhea
Contraindications
- Pregnancy Hypersensitivity Severe hapatic impairment Current treatment with teriflunomide
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is leflunomide?
leflunomide belongs to: Musculoskeletal.
How does leflunomide work?
Not fully understood, Metabolite inhibits pyrimidine nucleotide synthesis; antiproliferative for T-cells
What are the common side effects of leflunomide?
Alopecia, Rash, Nausea, Hypertension, Respiratory infections, Bronchitis, Diarrhea
Which drugs interact with leflunomide?
hepatitis a vaccine inactivated
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