Drug interactions
Leflunomide + Measles mumps rubella and varicella vaccine live
Severity: Contraindicated
Leflunomide and Measles mumps rubella and varicella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live attenuated combination vaccine may cause disseminated vaccine-strain infection, including varicella, in a patient immunosuppressed by leflunomide. The immune response may also be reduced.
What this interaction means in plain words
Leflunomide and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired lymphocyte function reduces control of live attenuated virus replication.
What to do
Avoid during leflunomide therapy and until washout is confirmed; vaccinate before treatment starts.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
- Alefacept + Leflunomide Major
Frequently asked questions
Can I take Leflunomide with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as contraindicated. Leflunomide and Measles mumps rubella and varicella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live attenuated combination vaccine may cause disseminated vaccine-strain infection, including varicella, in a patient immunosuppressed by leflunomide. The immune response may also be reduced.
How serious is the interaction between Leflunomide and Measles mumps rubella and varicella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during leflunomide therapy and until washout is confirmed; vaccinate before treatment starts.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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