Drug interactions
Leflunomide + Measles mumps and rubella vaccine live
Severity: Contraindicated
Leflunomide and Measles mumps and rubella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live attenuated vaccine may cause disseminated infection in a patient immunosuppressed by leflunomide. The immune response may also be inadequate.
What this interaction means in plain words
Leflunomide and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired lymphocyte function reduces control of live attenuated virus replication.
What to do
Avoid during leflunomide therapy and until washout is confirmed; give before treatment starts.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Leflunomide and Measles mumps and rubella vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
- Alefacept + Leflunomide Major
Frequently asked questions
Can I take Leflunomide with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Leflunomide and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live attenuated vaccine may cause disseminated infection in a patient immunosuppressed by leflunomide. The immune response may also be inadequate.
How serious is the interaction between Leflunomide and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during leflunomide therapy and until washout is confirmed; give before treatment starts.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
