Drug interactions
Influenza virus vaccine quadrivalent intranasal + Oseltamivir
Severity: Moderate
Influenza virus vaccine quadrivalent intranasal and Oseltamivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oseltamivir inhibits neuraminidase and can suppress replication of the live attenuated influenza virus in the intranasal vaccine. This may reduce the immune response and vaccine effectiveness.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Oseltamivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiviral inhibition of replication of the live attenuated vaccine virus.
What to do
Do not give the intranasal live vaccine within 2 weeks after starting or 48 hours before oseltamivir unless medically needed. Use an inactivated vaccine if immunization cannot be delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oseltamivir
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Oseltamivir?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent intranasal and Oseltamivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oseltamivir inhibits neuraminidase and can suppress replication of the live attenuated influenza virus in the intranasal vaccine. This may reduce the immune response and vaccine effectiveness.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Oseltamivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the intranasal live vaccine within 2 weeks after starting or 48 hours before oseltamivir unless medically needed. Use an inactivated vaccine if immunization cannot be delayed.
What other medicines interact with Oseltamivir?
MediHelp also lists interactions of Oseltamivir with, for example, Clopidogrel, Pretomanid, Probenecid. The full list is on the Oseltamivir page.
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