Drug interactions
Oseltamivir + Probenecid
Severity: Minor
Oseltamivir and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid approximately doubles exposure to oseltamivir carboxylate, the active metabolite, by reducing its renal secretion. The increase is not considered clinically significant given the drug's safety margin.
What this interaction means in plain words
Oseltamivir and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oseltamivir belongs to Anti Virals; Probenecid belongs to Genitourinary.
Why it happens
Probenecid blocks renal tubular anionic secretion of oseltamivir carboxylate.
What to do
No dose adjustment is required. Monitor for nausea or vomiting in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Oseltamivir
Frequently asked questions
Can I take Oseltamivir with Probenecid?
MediHelp rates the interaction as minor. Oseltamivir and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid approximately doubles exposure to oseltamivir carboxylate, the active metabolite, by reducing its renal secretion. The increase is not considered clinically significant given the drug's safety margin.
How serious is the interaction between Oseltamivir and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for nausea or vomiting in patients with renal impairment.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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