Drug interactions
Oseltamivir + Vadadustat
Severity: Minor
Oseltamivir and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits organic anion transporter 3, and oseltamivir carboxylate is eliminated renally partly via this transporter. Coadministration could raise oseltamivir carboxylate exposure, though the clinical consequence is probably small given oseltamivir's wide safety margin.
What this interaction means in plain words
Oseltamivir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oseltamivir belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT3-mediated tubular secretion of oseltamivir carboxylate by vadadustat.
What to do
No routine dose change is needed; monitor for gastrointestinal or neuropsychiatric adverse effects of oseltamivir, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oseltamivir
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Oseltamivir with Vadadustat?
MediHelp rates the interaction as minor. Oseltamivir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits organic anion transporter 3, and oseltamivir carboxylate is eliminated renally partly via this transporter. Coadministration could raise oseltamivir carboxylate exposure, though the clinical consequence is probably small given oseltamivir's wide safety margin.
How serious is the interaction between Oseltamivir and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for gastrointestinal or neuropsychiatric adverse effects of oseltamivir, particularly in patients with renal impairment.
What other medicines interact with Oseltamivir?
MediHelp also lists interactions of Oseltamivir with, for example, Influenza virus vaccine quadrivalent intranasal, Clopidogrel, Pretomanid. The full list is on the Oseltamivir page.
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