Drug interactions
Clopidogrel + Oseltamivir
Severity: Minor
Clopidogrel and Oseltamivir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oseltamivir is a prodrug activated by carboxylesterase 1, which clopidogrel can inhibit in vitro. This could lower formation of the active oseltamivir carboxylate, though clinical relevance has not been established.
What this interaction means in plain words
Clopidogrel and Oseltamivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Oseltamivir belongs to Anti Virals.
Why it happens
Possible inhibition of carboxylesterase 1-mediated activation of oseltamivir by clopidogrel.
What to do
No routine dose change is needed. Monitor clinical response to oseltamivir in severe influenza and consider this if response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oseltamivir
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Oseltamivir?
MediHelp rates the interaction as minor. Clopidogrel and Oseltamivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oseltamivir is a prodrug activated by carboxylesterase 1, which clopidogrel can inhibit in vitro. This could lower formation of the active oseltamivir carboxylate, though clinical relevance has not been established.
How serious is the interaction between Clopidogrel and Oseltamivir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor clinical response to oseltamivir in severe influenza and consider this if response is poor.
What other medicines interact with Oseltamivir?
MediHelp also lists interactions of Oseltamivir with, for example, Influenza virus vaccine quadrivalent intranasal, Pretomanid, Probenecid. The full list is on the Oseltamivir page.
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