Drug interactions
Oseltamivir + Pretomanid
Severity: Minor
Oseltamivir and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, and oseltamivir carboxylate is eliminated by renal tubular secretion involving OAT transporters. Exposure to oseltamivir carboxylate could rise, though oseltamivir has a wide safety margin.
What this interaction means in plain words
Oseltamivir and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oseltamivir belongs to Anti Virals; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of oseltamivir carboxylate.
What to do
No routine dose change is needed. Watch for increased gastrointestinal or neuropsychiatric adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oseltamivir
Other interactions of Pretomanid
Frequently asked questions
Can I take Oseltamivir with Pretomanid?
MediHelp rates the interaction as minor. Oseltamivir and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, and oseltamivir carboxylate is eliminated by renal tubular secretion involving OAT transporters. Exposure to oseltamivir carboxylate could rise, though oseltamivir has a wide safety margin.
How serious is the interaction between Oseltamivir and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for increased gastrointestinal or neuropsychiatric adverse effects, especially in renal impairment.
What other medicines interact with Oseltamivir?
MediHelp also lists interactions of Oseltamivir with, for example, Influenza virus vaccine quadrivalent intranasal, Clopidogrel, Probenecid. The full list is on the Oseltamivir page.
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