Drug interactions
Influenza virus vaccine quadrivalent intranasal + Vedolizumab
Severity: Moderate
Influenza virus vaccine quadrivalent intranasal and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus. Vedolizumab is gut-selective, but its labeling advises against live vaccines unless benefit outweighs risk. Replication of the vaccine virus in a patient with altered immunity is a theoretical concern and the immune response may be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Theoretical impairment of immune control of live attenuated virus by vedolizumab, which has a gut-selective effect on lymphocyte trafficking.
What to do
Use an inactivated injectable influenza vaccine instead of the live intranasal product in patients on vedolizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Vedolizumab?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent intranasal and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The intranasal influenza vaccine contains live attenuated virus. Vedolizumab is gut-selective, but its labeling advises against live vaccines unless benefit outweighs risk. Replication of the vaccine virus in a patient with altered immunity is a theoretical concern and the immune response may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead of the live intranasal product in patients on vedolizumab.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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