Drug interactions
Influenza virus vaccine quadrivalent recombinant + Temsirolimus
Severity: Minor
Influenza virus vaccine quadrivalent recombinant and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is immunosuppressive and may blunt the antibody response to vaccination. The recombinant vaccine is non-live and safe to give, but protection may be lower than in immunocompetent patients.
What this interaction means in plain words
Influenza virus vaccine quadrivalent recombinant and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and so reduces the immune response to vaccine antigens.
What to do
Vaccination is still recommended; ideally give it before starting temsirolimus or between cycles, and do not rely on it alone for protection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent recombinant with Temsirolimus?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent recombinant and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Temsirolimus is immunosuppressive and may blunt the antibody response to vaccination. The recombinant vaccine is non-live and safe to give, but protection may be lower than in immunocompetent patients.
How serious is the interaction between Influenza virus vaccine quadrivalent recombinant and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination is still recommended; ideally give it before starting temsirolimus or between cycles, and do not rely on it alone for protection.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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