Drug interactions
Influenza virus vaccine trivalent adjuvanted + Ocrelizumab
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab-induced B-cell depletion reduces antibody responses to inactivated influenza vaccine, so protection may be weaker. The vaccine remains safe and is still generally worthwhile.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Depletion of CD20-positive B cells impairs humoral immune responses to vaccine antigens.
What to do
Give inactivated influenza vaccine at least 2 weeks before ocrelizumab where feasible. Otherwise vaccinate as recommended, recognizing a reduced response, and reinforce other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza virus vaccine trivalent adjuvanted and Ocrelizumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Ocrelizumab?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab-induced B-cell depletion reduces antibody responses to inactivated influenza vaccine, so protection may be weaker. The vaccine remains safe and is still generally worthwhile.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated influenza vaccine at least 2 weeks before ocrelizumab where feasible. Otherwise vaccinate as recommended, recognizing a reduced response, and reinforce other preventive measures.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
